Bioregulator Tetrapeptide
Bioregulator tetrapeptides are short synthetic peptides developed at the St. Petersburg Institute of Bioregulation and Gerontology under Vladimir Khavinson's group. The class is built on the hypothesis that short peptide bioregulators bind specific DNA sequences and modulate tissue-specific gene expression. Epitalon (Ala-Glu-Asp-Gly) is the pineal-derived bioregulator; Pinealon (Glu-Asp-Arg) is a tripeptide bioregulator targeting brain tissue. Russian clinical literature describes decades of use; mainstream Western RCT-grade evidence is limited.
