Anti-Inflammatory Peptide
Anti-inflammatory peptides act on cytokine signaling, NF-kappaB activation, mast-cell degranulation, and leukocyte trafficking. KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH and retains the anti-inflammatory activity of the parent hormone without its melanogenic activity. Mechanisms include melanocortin receptor signaling and direct intracellular inhibition of NF-kappaB. Research applications span inflammatory bowel disease and dermatologic inflammation.
