NO. 015 · STAGE 1 · Lv. 70 · HP 150
5-AMINO-1MQ
Small-molecule NNMT inhibitor · body-composition research
ALIASES
5A1MQ, 5-amino-1-methylquinolinium iodide, NNMT inhibitor
CLASS
Small-molecule NNMT inhibitor (not a peptide)
FORMULA
C10H11IN2
HALF-LIFE
Short plasma half-life (oral bioavailable)
ROUTES
Oral (in animal studies) · Subcutaneous (research)
MECHANISM OF ACTION
5-Amino-1-methylquinolinium iodide. Selective inhibitor of nicotinamide N-methyltransferase (NNMT). Blocking NNMT raises intracellular NAD+ and SAM pools, theorized to drive lipolysis and improve insulin sensitivity in adipose tissue.
EVIDENCE GRADES
Well-characterized small-molecule inhibitor of nicotinamide N-methyltransferase.
Neelakantan et al. 2017 reported reduced adipose mass in diet-induced obese mice without changes in food intake.
No completed human Phase 2/3 trials. Most evidence preclinical.
MECHANISM CATEGORIES
RESEARCH CONDITIONS
SAFETY
Side effects
- Limited human safety data
- Animal studies report wide therapeutic window
Drug interactions
- Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM)
Contraindications
- Pregnancy/lactation (unstudied)
REGULATORY STATUS
FDA · Not FDA-approved. Research chemical.
WADA · Not currently listed on the WADA Prohibited List (2026).
STORAGE
Lyophilized · Room temperature in sealed container, light-protected
Reconstituted · Stable in aqueous solution; refrigerate
PEER-REVIEWED EVIDENCE
- Kraus D, Yang Q, Kong D, et al.. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 2014. link →
- Neelakantan H, Vance V, Wetzel MD, et al.. Selective NNMT inhibitor (5-amino-1MQ) reduces adiposity in DIO mice. J Med Chem 2017. link →
FAQ · 7 QUESTIONS
▶ What is 5-amino-1MQ?
5-amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine (SAM).
▶ Is 5-amino-1MQ a peptide?
No. 5-amino-1MQ is a small-molecule research chemical, not a peptide. It is included in the PEPPUDEX because it intersects with the NAD+/SAM/methionine-cycle longevity research that the wider peptide community follows.
▶ How does 5-amino-1MQ work?
By inhibiting NNMT, 5-amino-1MQ blocks the methylation of nicotinamide. The result is preserved intracellular pools of nicotinamide (→ NAD+ salvage substrate) and SAM (→ methyl-donor pool). In adipose tissue, NNMT is overexpressed in obesity; inhibition has been shown to reduce adipose mass in diet-induced obese mice.
▶ Is 5-amino-1MQ FDA-approved?
No. 5-amino-1MQ is a research chemical. No human clinical trials have completed as of 2026.
▶ Is 5-amino-1MQ banned in sports?
Not currently listed on the WADA Prohibited List as of 2026.
▶ What is NNMT?
Nicotinamide N-methyltransferase. The enzyme that transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide. NNMT is overexpressed in obese adipose tissue and is theorized to deplete SAM and NAD+ pools in adipocytes, contributing to metabolic dysfunction.
▶ Side effects of 5-amino-1MQ?
Limited human safety data. Animal studies report wide therapeutic windows. Theoretical concerns include methyl-donor depletion with chronic dosing.
SIGNATURE MOVES
Inhibits nicotinamide methylation in adipose tissue.
Raises NAD+ + SAM pools · drives white-adipose lipolysis.
SOURCED FROM PEPPU LABS
Reference compounds documented on this page are available as research-grade material at Peppu Studio · ≥99% purity · per-batch Certificate of Analysis. For laboratory research use only. No human dose is recommended by this wiki.
▶ LAST UPDATED · 2026-05-19