NO. 036 · BASIC · Lv. 60 · HP 95
DSIP
Delta Sleep-Inducing Peptide
ALIASES
DSIP, delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
CLASS
Endogenous nonapeptide · sleep / stress-pathway modulator
FORMULA
C35H48N10O15
SEQUENCE
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
HALF-LIFE
Very short (minutes) plasma · longer CNS retention reported
ROUTES
Subcutaneous (research) · Intranasal (research)
MECHANISM OF ACTION
Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood during electrically induced sleep states. Modulates delta-wave EEG signaling in animal models; mechanism not fully characterized. Investigated for sleep, stress, and chronic pain.
EVIDENCE GRADES
Original Schoenenberger 1977 isolation paper described EEG-pattern shift toward slow-wave sleep in rabbits.
Russian preclinical literature on stress-axis modulation. Limited Western replication.
Limited published Western RCT evidence. Russian clinical literature describes use as sleep aid; no FDA or EMA trials.
MECHANISM CATEGORIES
RESEARCH CONDITIONS
SAFETY
Side effects
- Limited published safety data
- Reported well-tolerated in small Russian studies
Known interactions
- GABAergic medications (theoretical · unstudied)
- Benzodiazepines (theoretical additive sedation)
Contraindications
- Pregnancy/lactation (unstudied)
- Hypersensitivity
REGULATORY STATUS
FDA · Not FDA-approved. Research-use only.
WADA · Not currently listed on the WADA Prohibited List (2026).
STORAGE
Lyophilized · -20 °C 24 months
Reconstituted · 2-8 °C, 14-28 days
PEER-REVIEWED EVIDENCE
- Schoenenberger GA, Monnier M. The isolation of a peptide which induces delta-sleep. Pflugers Arch 1977. PMID 195243. link →
- Graf MV, Kastin AJ. Delta sleep-inducing peptide (DSIP): a review. Peptides 1986. link →
FAQ · 8 QUESTIONS
▶ What is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated by Monnier and Schoenenberger from rabbit cerebral venous blood during electrically induced sleep states in 1977. The sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
▶ How does DSIP work?
Mechanism is not fully characterized. Animal-model studies describe modulation of delta-wave EEG, HPA-axis stress response, and central monoamine signaling. No specific receptor has been definitively identified. Russian preclinical literature is the main evidence base.
▶ Is DSIP FDA-approved?
No. DSIP is research-use only. No FDA-approved indication.
▶ Is DSIP WADA-prohibited?
DSIP is not currently listed on the WADA Prohibited List as of 2026.
▶ What's the half-life of DSIP?
Very short plasma half-life (minutes). CNS retention is reportedly longer, but the molecule is rapidly cleared from circulation. This is why research protocols typically use subcutaneous administration shortly before the intended sleep onset.
▶ DSIP vs melatonin · which is better for sleep?
Different mechanisms. Melatonin is the endogenous pineal hormone that signals circadian timing and is the standard research-supported sleep-onset compound. DSIP acts on a less-characterized delta-wave pathway and lacks the same evidence base. Melatonin is the better-validated research sleep aid.
▶ What is the research dose of DSIP?
Russian preclinical literature describes 25-100 mcg per administration, subcutaneous or intranasal, prior to sleep. No human dose is recommended by this wiki.
▶ Has DSIP been studied in chronic pain?
Russian clinical literature describes use as an adjunct in chronic pain syndromes, particularly with concurrent sleep disturbance. Limited Western replication.
APPEARS IN STACKS
SIGNATURE MOVES
Modulates slow-wave EEG. Animal-model sleep enhancement.
HPA-axis modulation in rodent stress paradigms.
SOURCED FROM PEPPU LABS
Reference compounds documented on this page are available as research-grade material at Peppu Studio · ≥99% purity · per-batch Certificate of Analysis. For laboratory research use only. No human dose is recommended by this wiki.
▶ LAST UPDATED · 2026-05-25